Publications

Selected Publications

Chaudhari, S.N., Luo, J.N., Harris, D.A., Aliakbarian, H., Yao, L., Paik, D., Subramaniam, R., Adhikari, A.A., Vernon, A.H., Kilic, A., Weiss, S.T., Huh, J.R., Sheu, E.G., Devlin, A.S. A microbial metabolite remodels the gut-liver axis following bariatric surgery. Cell Host Microbe 2021. [link]

Chaudhari, S.N., Harris, D.A., Aliakbarian, H., Luo, J.N., Henke, M.T., Subramaniam, R., Vernon, A.H., Tavakkoli, A., Sheu, E.G., Devlin, A.S. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nat. Chem. Biol. 2021, 17, 20. [link]
Press Coverage: C&E News Nature Chemical Biology News&Views  HMS News and Research

Adhikari, A.A., Seegar, T.C.M., Ficarro, S.B., McCurry, M.D., Ramachandran, D., Yao, L., Chaudhari, S.N., Ndousse-Fetter, S., Banks, A.S., Marto, J.A., Blacklow, S.C., Devlin, A.S. “Development of a covalent inhibitor of gut bacterial bile salt hydrolases.” Nat. Chem. Biol. 2020, 16, 318. [link]

Hang, S., Paik, D., Yao, L., Kim, E., Jamma, T., Lu, J., Ha, S., Nelson, B.N., Kelly, S.P., Wu, L., Zheng, Y., Longman, R.S., Rastinejad, F., Devlin, A.S.,  Krout, M.R., Fischbach, M.A., Littman, D.R., Huh, J.R. “Bile acid metabolites control TH17 and Treg cell differentiation.” Nature 2019, 576, 143. [link]

Yao, L., Seaton, S.C., Ndousse-Fetter, S., Adhikari, A.A., DiBenedetto, N., Mina, A.I., Banks, A.S., Bry, L. & Devlin, A.S. “A Selective Gut Bacterial Bile Salt Hydrolase Alters Host Metabolism.”eLife 2018, 7:e37182. [link]
Press Coverage: HMS News and Research   Science Daily

Devlin, A.S., Marcobal, A., Dodd, D., Nayfach, S., Plummer, N., Meyer, T., Pollard, K.S., Sonnenburg, J.L. & Fischbach, M.A. “Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.” Cell Host Microbe 2016, 20, 709. [link]

Toma, T., Logan, M.M., Menard, F., Devlin, A.S., Du Bois, J. “Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.” ACS Chem. Neurosci. 2016, 7, 1463. [link]

Devlin, A.S. & Fischbach, M.A. “A biosynthetic pathway for a prominent class of microbiota-derived bile acids.” Nat. Chem. Biol. 2015, 11, 685. [link]

David, L.A., Maurice, C.M., Carmody, R.N., Gootenberg, D.B., Button, J.E., Wolfe, B.E., Ling, A.V., Devlin, A.S., Varma, Y., Fischbach, M.A., Biddinger, S.B., Dutton, R.J. & Turnbaugh, P.J. “Diet rapidly and reproducibly alters the human gut microbiome.” Nature 2014, 505, 559. [link]

Devlin, A.S. & Du Bois, J. “Modular Synthesis of the Pentacyclic Core of Batrachotoxin and Select Batrachotoxin Analogue Designs.” Chem. Sci. 2013, 4, 1053. [link]

Wolckenhauer, S.A., Devlin, A.S. & Du Bois, J. “δ-Sultone Formation Through Rh-Catalyzed C–H Insertion.” Org. Lett. 2007, 9, 4363. [link]

Pre-prints

Paik, D., Yao, L., Zhang, Y., Bae, S., D’Agostino, G.D., Kim, E., Frazosa, E.A., Avila-Pacheco, J., Bisanz, J.E., Rakowski, C.K., Vlamakis, H., Xavier, R.J., Turnbaugh, P.J., Longman, R.S., Krout, M.R., Clish, C.B., Huttenhower, C., Huh, J.R., Devlin, A.S. “Human gut bacteria produce Th17-modulating bile acid metabolites.” bioRxiv 2021 [link]

Li, W., Hang, S., Fang, Y., Bae, S., Zhang, Y., Wang, G., McCurry, M.D., Bae, M., Frazosa, E.A., Huttenhower, C., Yao, L., Devlin, A.S., Huh, J.R. “A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4AI.” bioRxiv 2021 [link]

Patents

Du Bois, J., Devlin, A.S., Menard, F., Logan, M. & Toma, T. “Batrachotoxin Analogues, Compositions, Uses, and Preparation Thereof.” US Patent No. 9,090,627.