Publications

Selected Publications

Chaudhari S.N., McCurry, M.D., Devlin A.S. “Chains of evidence from correlations to causal molecules in microbiome-linked diseases.” Nat. Chem. Biol. 2021, 17, 1046. [link]
Press Coverage: Featured on the cover of Nature Chemical Biology

Li, W., Hang, S., Fang, Y., Bae, S., Zhang, Y., Wang, G., McCurry, M.D., Bae, M., Frazosa, E.A., Huttenhower, C., Yao, L., Devlin, A.S., Huh, J.R. “A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4AI.” Cell Host Microbe 2021 [link]

Adhikari, A.A., Ramachandran, D., Chaudhari, S.N., Powell, C.E., McCurry, M.D., Banks, A.S., Devlin, A.S. “A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases.” ACS Chem. Biol. 2021 [link]

Chaudhari S.N., Devlin A.S. “Intestinal co-culture system to study TGR5 agonism and gut restriction.” Bio-protocol 2021, 11, 6. [link]

Chaudhari, S.N., Luo, J.N., Harris, D.A., Aliakbarian, H., Yao, L., Paik, D., Subramaniam, R., Adhikari, A.A., Vernon, A.H., Kilic, A., Weiss, S.T., Huh, J.R., Sheu, E.G., Devlin, A.S. “A microbial metabolite remodels the gut-liver axis following bariatric surgery.” Cell Host Microbe 2021 [link]

Chaudhari, S.N., Harris, D.A., Aliakbarian, H., Luo, J.N., Henke, M.T., Subramaniam, R., Vernon, A.H., Tavakkoli, A., Sheu, E.G., Devlin, A.S. “Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects.” Nat. Chem. Biol. 2021, 17, 20. [link]
Press Coverage: C&E News  Nature Chemical Biology News&Views  HMS News and Research  Translational Chemical Biology conference press highlight  Cell Host & Microbe preview

Adhikari, A.A., Seegar, T.C.M., Ficarro, S.B., McCurry, M.D., Ramachandran, D., Yao, L., Chaudhari, S.N., Ndousse-Fetter, S., Banks, A.S., Marto, J.A., Blacklow, S.C., Devlin, A.S. “Development of a covalent inhibitor of gut bacterial bile salt hydrolases.” Nat. Chem. Biol. 2020, 16, 318. [link]
Press Coverage: Featured on the cover of Nature Chemical Biology

Hang, S., Paik, D., Yao, L., Kim, E., Jamma, T., Lu, J., Ha, S., Nelson, B.N., Kelly, S.P., Wu, L., Zheng, Y., Longman, R.S., Rastinejad, F., Devlin, A.S.,  Krout, M.R., Fischbach, M.A., Littman, D.R., Huh, J.R. “Bile acid metabolites control TH17 and Treg cell differentiation.” Nature 2019, 576, 143. [link]

Yao, L., Seaton, S.C., Ndousse-Fetter, S., Adhikari, A.A., DiBenedetto, N., Mina, A.I., Banks, A.S., Bry, L. & Devlin, A.S. “A Selective Gut Bacterial Bile Salt Hydrolase Alters Host Metabolism.”eLife 2018, 7:e37182. [link]
Press Coverage: HMS News and Research   Science Daily

Devlin, A.S., Marcobal, A., Dodd, D., Nayfach, S., Plummer, N., Meyer, T., Pollard, K.S., Sonnenburg, J.L. & Fischbach, M.A. “Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.” Cell Host Microbe 2016, 20, 709. [link]

Toma, T., Logan, M.M., Menard, F., Devlin, A.S., Du Bois, J. “Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.” ACS Chem. Neurosci. 2016, 7, 1463. [link]

Devlin, A.S. & Fischbach, M.A. “A biosynthetic pathway for a prominent class of microbiota-derived bile acids.” Nat. Chem. Biol. 2015, 11, 685. [link]

David, L.A., Maurice, C.M., Carmody, R.N., Gootenberg, D.B., Button, J.E., Wolfe, B.E., Ling, A.V., Devlin, A.S., Varma, Y., Fischbach, M.A., Biddinger, S.B., Dutton, R.J. & Turnbaugh, P.J. “Diet rapidly and reproducibly alters the human gut microbiome.” Nature 2014, 505, 559. [link]

Devlin, A.S. & Du Bois, J. “Modular Synthesis of the Pentacyclic Core of Batrachotoxin and Select Batrachotoxin Analogue Designs.” Chem. Sci. 2013, 4, 1053. [link]

Wolckenhauer, S.A., Devlin, A.S. & Du Bois, J. “δ-Sultone Formation Through Rh-Catalyzed C–H Insertion.” Org. Lett. 2007, 9, 4363. [link]

Pre-prints

Paik, D., Yao, L., Zhang, Y., Bae, S., D’Agostino, G.D., Kim, E., Frazosa, E.A., Avila-Pacheco, J., Bisanz, J.E., Rakowski, C.K., Vlamakis, H., Xavier, R.J., Turnbaugh, P.J., Longman, R.S., Krout, M.R., Clish, C.B., Huttenhower, C., Huh, J.R., Devlin, A.S. “Human gut bacteria produce Th17-modulating bile acid metabolites.” bioRxiv 2021 [link]

Li, D.K., Chaudhari, S.N., Sojoodi, M., Lee, Y., Adhikari, A.A., Zhuo, Z., Zukerberg, L., Shroff, S., Barrett, S.C., Boursier, J., Diehl, A.M., Sui, S.H., Tanabe, K., Chung, R.T., Devlin, A.S. “Bile salt hydrolases deplete conjugated bile acids and erode gut barrier integrity in non-alcoholic steatohepatitis.” bioRxiv 2021 [link]

Patents

“Batrachotoxin Analogues, Compositions, Uses, and Preparation Thereof.” US Patent No. 9,090,627.

“Compositions and methods related to cholic acid-7-sulfate as a treatment for diabetes.” WO/2020/041673

“Small molecule modulators of gut bacterial bile acid metabolism.” WO/2020/231776

“Synthetic derivatives of cholic acid-7-sulfate and uses thereof.” WO/2020/117945