Yao, L., Seaton, S.C., Ndousse-Fetter, S., Adhikari, A.A., DiBenedetto, N., Mina, A.I., Banks, A.S., Bry, L. & Devlin, A.S.* “A Selective Gut Bacterial Bile Salt Hydrolase Alters Host Metabolism.”eLife.2018, 7:e37182. [link]
Press Coverage: HMS News and ResearchScience Daily
Devlin, A.S., Marcobal, A., Dodd, D., Nayfach, S., Plummer, N., Meyer, T., Pollard, K.S., Sonnenburg, J.L. & Fischbach, M.A. “Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.” Cell Host Microbe. 2016, 20, 709. [link]
Renal disease is a big problem in the US: $50 billion annually, ~500,000 people plus 8 million more with uremic symptoms. Dialysis and kidney transplantation are the only effective treatments currently, both of which have serious drawbacks for quality and duration of life. We propose a potential alternative treatment, which is to reduce the levels of damaging toxins, many of which are produced by human gut bacteria, by modulating the host’s microbiome.
Toma, T., Logan, M.M., Menard, F., Devlin, A.S., Du Bois, J. “Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.” ACS Chem. Neurosci.2016, 7, 1463. [link]
Devlin, A.S. & Fischbach, M.A. “A biosynthetic pathway for a prominent class of microbiota-derived bile acids.” Nat. Chem. Bio.2015, 11, 685. [link]
David, L.A., Maurice, C.M., Carmody, R.N., Gootenberg, D.B., Button, J.E., Wolfe, B.E., Ling, A.V., Devlin, A.S., Varma, Y., Fischbach, M.A., Biddinger, S.B., Dutton, R.J. & Turnbaugh, P.J. “Diet rapidly and reproducibly alters the human gut microbiome.” Nature2014, 505, 559. [link]
Devlin, A.S. & Du Bois, J. “Modular Synthesis of the Pentacyclic Core of Batrachotoxin and Select Batrachotoxin Analogue Designs.” Chem. Sci. 2013, 4, 1053. [link]
Wolckenhauer, S.A., Devlin, A.S. & Du Bois, J. “δ-Sultone Formation Through Rh-Catalyzed C–H Insertion.” Org. Lett.2007, 9, 4363. [link]
Du Bois, J., Devlin, A.S., Menard, F., Logan, M. & Toma, T. “Batrachotoxin Analogues, Compositions, Uses, and Preparation Thereof.” US Patent No. 9,090,627.