Publications

Selected Publications

Adhikari, A.A., Ramachandran, D., Chaudhari, S.N., Powell, C.E., McCurry, M.D., Banks, A.S., Devlin, A.S. “A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases.” ACS Chem. Biol. 2021 [link]

Chaudhari S.N., Devlin A.S. “Intestinal Co-culture System to Study TGR5 Agonism and Gut Restriction.” Bio-protocol 2021, 11, 6. [link]

Chaudhari, S.N., Luo, J.N., Harris, D.A., Aliakbarian, H., Yao, L., Paik, D., Subramaniam, R., Adhikari, A.A., Vernon, A.H., Kilic, A., Weiss, S.T., Huh, J.R., Sheu, E.G., Devlin, A.S. A microbial metabolite remodels the gut-liver axis following bariatric surgery. Cell Host Microbe 2021 [link]

Chaudhari, S.N., Harris, D.A., Aliakbarian, H., Luo, J.N., Henke, M.T., Subramaniam, R., Vernon, A.H., Tavakkoli, A., Sheu, E.G., Devlin, A.S. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nat. Chem. Biol. 2021, 17, 20. [link]
Press Coverage: C&E News  Nature Chemical Biology News&Views  HMS News and Research  Translational Chemical Biology conference press highlight  Cell Host & Microbe preview

Adhikari, A.A., Seegar, T.C.M., Ficarro, S.B., McCurry, M.D., Ramachandran, D., Yao, L., Chaudhari, S.N., Ndousse-Fetter, S., Banks, A.S., Marto, J.A., Blacklow, S.C., Devlin, A.S. “Development of a covalent inhibitor of gut bacterial bile salt hydrolases.” Nat. Chem. Biol. 2020, 16, 318. [link]

Hang, S., Paik, D., Yao, L., Kim, E., Jamma, T., Lu, J., Ha, S., Nelson, B.N., Kelly, S.P., Wu, L., Zheng, Y., Longman, R.S., Rastinejad, F., Devlin, A.S.,  Krout, M.R., Fischbach, M.A., Littman, D.R., Huh, J.R. “Bile acid metabolites control TH17 and Treg cell differentiation.” Nature 2019, 576, 143. [link]

Yao, L., Seaton, S.C., Ndousse-Fetter, S., Adhikari, A.A., DiBenedetto, N., Mina, A.I., Banks, A.S., Bry, L. & Devlin, A.S. “A Selective Gut Bacterial Bile Salt Hydrolase Alters Host Metabolism.”eLife 2018, 7:e37182. [link]
Press Coverage: HMS News and Research   Science Daily

Devlin, A.S., Marcobal, A., Dodd, D., Nayfach, S., Plummer, N., Meyer, T., Pollard, K.S., Sonnenburg, J.L. & Fischbach, M.A. “Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.” Cell Host Microbe 2016, 20, 709. [link]

Toma, T., Logan, M.M., Menard, F., Devlin, A.S., Du Bois, J. “Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.” ACS Chem. Neurosci. 2016, 7, 1463. [link]

Devlin, A.S. & Fischbach, M.A. “A biosynthetic pathway for a prominent class of microbiota-derived bile acids.” Nat. Chem. Biol. 2015, 11, 685. [link]

David, L.A., Maurice, C.M., Carmody, R.N., Gootenberg, D.B., Button, J.E., Wolfe, B.E., Ling, A.V., Devlin, A.S., Varma, Y., Fischbach, M.A., Biddinger, S.B., Dutton, R.J. & Turnbaugh, P.J. “Diet rapidly and reproducibly alters the human gut microbiome.” Nature 2014, 505, 559. [link]

Devlin, A.S. & Du Bois, J. “Modular Synthesis of the Pentacyclic Core of Batrachotoxin and Select Batrachotoxin Analogue Designs.” Chem. Sci. 2013, 4, 1053. [link]

Wolckenhauer, S.A., Devlin, A.S. & Du Bois, J. “δ-Sultone Formation Through Rh-Catalyzed C–H Insertion.” Org. Lett. 2007, 9, 4363. [link]

Pre-prints

Paik, D., Yao, L., Zhang, Y., Bae, S., D’Agostino, G.D., Kim, E., Frazosa, E.A., Avila-Pacheco, J., Bisanz, J.E., Rakowski, C.K., Vlamakis, H., Xavier, R.J., Turnbaugh, P.J., Longman, R.S., Krout, M.R., Clish, C.B., Huttenhower, C., Huh, J.R., Devlin, A.S. “Human gut bacteria produce Th17-modulating bile acid metabolites.” bioRxiv 2021 [link]

Li, W., Hang, S., Fang, Y., Bae, S., Zhang, Y., Wang, G., McCurry, M.D., Bae, M., Frazosa, E.A., Huttenhower, C., Yao, L., Devlin, A.S., Huh, J.R. “A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4AI.” bioRxiv 2021 [link]

Li, D.K., Chaudhari, S.N., Sojoodi, M., Lee, Y., Adhikari, A.A., Zhuo, Z., Zukerberg, L., Shroff, S., Barrett, S.C., Boursier, J., Diehl, A.M., Sui, S.H., Tanabe, K., Chung, R.T., Devlin, A.S. “Bile salt hydrolases deplete conjugated bile acids and erode gut barrier integrity in non-alcoholic steatohepatitis.” bioRxiv 2021 [link]

Patents

“Batrachotoxin Analogues, Compositions, Uses, and Preparation Thereof.” US Patent No. 9,090,627.

“Compositions and methods related to cholic acid-7-sulfate as a treatment for diabetes.” WO/2020/041673

“Small molecule modulators of gut bacterial bile acid metabolism.” WO/2020/231776

“Synthetic derivatives of cholic acid-7-sulfate and uses thereof.” WO/2020/117945