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Press Coverage: HMS News and ResearchScience Daily
Devlin, A.S., Marcobal, A., Dodd, D., Nayfach, S., Plummer, N., Meyer, T., Pollard, K.S., Sonnenburg, J.L. & Fischbach, M.A. “Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.” Cell Host Microbe. 2016, 20, 709. [link]
Renal disease is a big problem in the US: $50 billion annually, ~500,000 people plus 8 million more with uremic symptoms. Dialysis and kidney transplantation are the only effective treatments currently, both of which have serious drawbacks for quality and duration of life. We propose a potential alternative treatment, which is to reduce the levels of damaging toxins, many of which are produced by human gut bacteria, by modulating the host’s microbiome.
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