The Devlin lab at Harvard Medical School uses small molecules to study and manipulate human-associated bacteria in order to better understand how the microbiome affects human health and disease. The lab leverages expertise from different fields, including synthetic organic chemistry, molecular biology, microbiology, analytical chemistry, and bioinformatics.

We currently have positions for graduate students and undergraduates. In particular, we are actively seeking (1) potential students with an organic chemistry background interested in using chemistry to study biological problems and (2) microbiologists / biochemists interested in studying the human microbiome. If you are interested, get in touch.

 

New paper online:

Devlin et al. “Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.” Cell Host & Microbe, December 1, 2016. Link.

Renal disease is a big problem in the US: $50 billion annually, ~500,000 people plus 8 million more with uremic symptoms. Dialysis and kidney transplantation are the only effective treatments currently, both of which have serious drawbacks for quality and duration of life. We propose a potential alternative treatment, which is to reduce the levels of damaging toxins, many of which are produced by human gut bacteria, by modulating the host’s microbiome.